The ARF tumor suppressor: Structure, functions and status in cancer

Tumor suppressor ARF

ARF (alternative reading frame) is one of the most important tumor regulator playing critical roles in controlling tumor initiation and progression. Recently, we have demonstrated a novel and unexpected role for ARF as modulator of inflammatory responses.

Role of the ARF Tumor Suppressor in Prostate Cancer

Antiviral action of the tumor suppressor ARF.

Oncogenic viruses frequently target the pathways controlled by tumor suppressor genes, suggesting an extra function for these proteins as antiviral factors. The control exerted by the tumor suppressor Arf on cellular proliferation is crucial to restrict tumor development; however, a potential contribution of Arf to prevent viral infectivity has remained unexplored. In the present study, we inve...

Ubiquitination of, and sumoylation by, the Arf tumor suppressor.

The Ink4a-Arf locus, which encodes two distinct tumor suppressor proteins, is inactivated in many cancers. Whereas p16Ink4a is an inhibitor of cyclin D-dependent kinases, p19Arf (p14ARF in humans) antagonizes the E3 ubiquitin protein ligase activity of Mdm2 to activate p53. We now recognize that Arf functions in both p53-dependent and -independent modes to counteract hyper-proliferative signals...

Opposing Roles of Nucleophosmin and the ARF Tumor Suppressor in Breast Cancer PRINCIPAL INVESTIGATOR: